A Secret Weapon For https://www.ceesdekker.net
A Secret Weapon For https://www.ceesdekker.net
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Spatial composition facilitates cooperation in a social Predicament: empirical proof from the bacterial Group
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Round the identical time, the team of Paul McEuen, who was then dependent on the College of California, Berkeley, showed similar success on ropes of bundled nanotubes. Depending upon the wrapping angle, nanotubes can are available in metallic or semiconducting variants, a prediction that we and Charles Lieber’s team at Harvard University independently verified employing scanning tunnelling spectroscopy experiments.
Sculpting nano-electrodes that has a transmission electron beam for electrical and geometrical characterization of nanoparticles.
That could be a desire of mine and we set to work that has a delicious dose of naivety. That is a thing that will probably produce impressive results in the more time time period, but that doesn't make a difference. You should not only want to operate over the concerns of tomorrow, and also over the queries with the working day following tomorrow.’
SMC complexes can pass physical roadblocks larger than their ring measurement, indicating a nontopological mechanism for DNA loop extrusion
What distinguishes biology from chemistry is the fact that these parts with each other make up a residing system. The key of said lifetime, I think, lies from the interactions, the interplay of All those molecules. The big concern about the origin of daily life is still unanswered. How did we ever evolve from uncomplicated molecules in to the particularly complex programs we see now? We have no idea. I would like to operate on These types of large, open issues.’
Studying DNA loop extrusion by SMC proteins for chromosome architecture with solitary-molecule assays.
Knowing basic processes regulating the spatial and dynamic organisation of the DNA in live cells.
Presently, we also recognized that it should be achievable to make use of just one semiconducting carbon nanotube to create a transistor — and we established out to really make it. We stretched specific semiconducting nanotubes across metallic electrodes and utilized the fundamental silicon substrate to be a gate electrode, developing The fundamental three-terminal structure of the discipline-effect transistor (Fig.
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Cees Dekker is Distinguished University Professor at TU Delft. Educated as being a physicist, he pioneered nanotechnology with numerous discoveries on carbon nanotubes while in the nineties. Given that 2000, he moved to single-molecule biophysics and nanobiology. His present study concentrates on (i) nanopores for protein sequencing; (ii) chromosome composition, specifically SMC motor protein; and (iii) creating a residing synthetic mobile from lifeless molecules. Dekker is really an elected member on the KNAW and fellow on the APS as well as the IOP.
Visualization of unstained DNA nanostructures with advanced in-concentrate transmission electron microscopy tactics
Reliable-condition nanopores have established to get a amazingly functional probe for solitary-molecule Examination of DNA. I will describe some of our recent conclusions – precisely DNA knots https://www.ceesdekker.net – and our initiatives to develop the capabilities of sound-state nanopores even further, in the way of solitary-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.